化学
胺化
催化作用
氧化还原
光催化
还原胺化
光化学
烷氧基
酒精氧化
电子转移
组合化学
氢原子
有机化学
烷基
作者
Ni Xiong,Yang Li,Rong Zeng
出处
期刊:Organic Letters
[American Chemical Society]
日期:2021-10-29
卷期号:23 (22): 8968-8972
被引量:50
标识
DOI:10.1021/acs.orglett.1c03488
摘要
We report a general photocatalytic protocol for the remote C(sp3)-H bond amination of free aliphatic alcohols. The electron transfer between the abundant and inexpensive catalyst FeCl3 and simple alkanols under blue LED irradiation enables the alkoxy radical formation under mild redox-neutral conditions, with no need for additional oxidant and prefunctionalization. The subsequent selective 1,5-hydrogen atom transfer (HAT) and amination provide a simple and efficient way to access molecular complexity from readily available and bulk alcohols.
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