线粒体
细胞生物学
巨噬细胞
细胞代谢
生物
免疫系统
新陈代谢
重编程
活性氧
功能(生物学)
能量代谢
细胞呼吸
细胞
生物化学
免疫学
内分泌学
体外
作者
Mohamed Zakaria Nassef,Jasmin E. Hanke,Karsten Hiller
出处
期刊:American Journal of Physiology-cell Physiology
[American Physiological Society]
日期:2021-10-27
卷期号:321 (6): C1070-C1081
被引量:13
标识
DOI:10.1152/ajpcell.00126.2021
摘要
Mitochondria are considered to be the powerhouse of the cell. Normal functioning of the mitochondria is not only essential for cellular energy production but also for several immunomodulatory processes. Macrophages operate in metabolic niches and rely on rapid adaptation to specific metabolic conditions such as hypoxia, nutrient limitations, or reactive oxygen species to neutralize pathogens. In this regard, the fast reprogramming of mitochondrial metabolism is indispensable to provide the cells with the necessary energy and intermediates to efficiently mount the inflammatory response. Moreover, mitochondria act as a physical scaffold for several proteins involved in immune signaling cascades and their dysfunction is immediately associated with a dampened immune response. In this review, we put special focus on mitochondrial function in macrophages and highlight how mitochondrial metabolism is involved in macrophage activation.
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