效应器
糖酵解
癌症免疫疗法
节食
功能(生物学)
医学
肿瘤微环境
癌细胞
癌症研究
免疫疗法
癌症
FOXP3型
免疫系统
细胞生物学
免疫学
生物
作者
Clarissa Campbell,Alexander Y. Rudensky
标识
DOI:10.1016/j.cmet.2021.04.010
摘要
Glycolysis supports effector T cell function but is detrimental to the immunosuppressive activity of regulatory T cells. In a recent issue of Nature, two papers address a role for glucose and lactate availability within the tumor microenvironment for the balance of pro- and anti-tumoral effects of T cells and the efficacy of neoadjuvant cancer immunotherapy.
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