医学
免疫原性
艾滋病疫苗
临床试验
人类免疫缺陷病毒(HIV)
疫苗试验
疫苗效力
病毒学
免疫学
内科学
接种疫苗
免疫系统
作者
Susan Zolla-Pazner,Nelson L. Michael,Jerome H. Kim
出处
期刊:The Lancet HIV
[Elsevier]
日期:2021-07-01
卷期号:8 (7): e449-e452
被引量:7
标识
DOI:10.1016/s2352-3018(21)00073-4
摘要
The advanced-phase HIV prevention vaccine trials done in South Africa (HVTN 702) and in Thailand (RV144), which both investigated canarypox vectors and adjuvanted gp120 proteins, gave rise to different results. The South African trial did not find vaccine efficacy, whereas the Thai trial had modest, but statistically significant, success with the modified intention-to-treat analysis prespecified in the protocols of both studies. An understanding of the differences between the studies is required to avoid the possible, but erroneous, conclusion that the results from the South African trial negatively affect the results of the Thai trial.
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