已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

Differentiation of low- and high-grade pediatric gliomas with amide proton transfer imaging: added value beyond quantitative relaxation times

医学 接收机工作特性 神经组阅片室 胶质瘤 逻辑回归 曼惠特尼U检验 曲线下面积 核医学 逐步回归 多元分析 放射科 内科学 神经学 精神科 癌症研究
作者
Hongxi Zhang,Xingwang Yong,Xiaomeng Ma,Jun Zhao,Zhipeng Shen,Xinchun Chen,Feng-yu Tian,Weibo Chen,Dan Wu,Yi Zhang
出处
期刊:European Radiology [Springer Nature]
卷期号:31 (12): 9110-9119 被引量:12
标识
DOI:10.1007/s00330-021-08039-w
摘要

ObjectivesTo evaluate whether amide proton transfer (APT) MRI can be used to characterize gliomas in pediatric patients and whether it provides added value beyond relaxation times.MethodsIn this prospective study, APT imaging and relaxation time mapping were performed in 203 pediatric patients suspected of gliomas from February 2018 to December 2019. The region of interest (ROI) in the tumor was automatically generated with artifact detection and ROI-shrinking algorithms. Several APT-related metrics (CESTR, CESTRnr, MTRRex, AREX, and APT#) and quantitative T1 and T2 were compared between low-grade and high-grade gliomas using the student’s t-test or Mann-Whitney U-test. The performance of these parameters was assessed using the receiver operating characteristic (ROC) analysis. A stepwise multivariate logistic regression model was used to combine the imaging parameters.ResultsForty-eight patients (mean age: 6 ± 4 years; 23 males and 25 females) were included in the final analysis. All the APT-related metrics except APT# had significantly (p < 0.05) higher values in the high-grade group than the low-grade group. Under different ROI-shrinking cutoffs, the quantitative T1 (p = 0.045–0.200) and T2 (p = 0.037–0.171) values of high-grade gliomas were typically lower than those of low-grade ones. The stepwise multivariate logistic regression revealed that CESTRnr and APT# were combined significant predictors of glioma grades (p < 0.05), with an area under the ROC curve (AUC) of 0.86 substantially larger than those of T1 (AUC = 0.69) and T2 (AUC = 0.68).ConclusionsAPT imaging can be used to differentiate high-grade and low-grade gliomas in pediatric patients and provide added value beyond quantitative relaxation times.Key Points • Amide proton transfer (APT) MRI showed significantly (p < 0.05) higher values in pediatric patients with high-grade gliomas than those with low-grade ones. • The area under the curve was 0.86 for APT MRI to differentiate low-grade and high-grade gliomas in pediatric patients, which was substantially higher than that for quantitative T1 (0.69) and T2 (0.68). • APT MRI demonstrated added value beyond quantitative T1 and T2 mapping in characterizing pediatric gliomas.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
学术废物完成签到 ,获得积分10
刚刚
Mob发布了新的文献求助30
2秒前
llnysl完成签到 ,获得积分10
2秒前
ddbb完成签到 ,获得积分10
3秒前
开放菀完成签到 ,获得积分10
4秒前
cxmy完成签到 ,获得积分10
6秒前
overmind完成签到,获得积分10
6秒前
酒石酸美托洛尔i完成签到,获得积分10
9秒前
9秒前
焱焱不忘完成签到 ,获得积分10
12秒前
深情安青应助wlp鹏采纳,获得10
15秒前
汉堡包应助科研通管家采纳,获得10
16秒前
VDC应助科研通管家采纳,获得10
16秒前
一枝鸭应助科研通管家采纳,获得10
16秒前
情怀应助科研通管家采纳,获得10
16秒前
顾矜应助科研通管家采纳,获得10
16秒前
科研通AI2S应助科研通管家采纳,获得10
16秒前
Peng应助科研通管家采纳,获得10
16秒前
17秒前
18秒前
MYZ完成签到 ,获得积分10
20秒前
深情安青应助亦阳采纳,获得10
23秒前
23秒前
憨憨发布了新的文献求助10
25秒前
赋成完成签到 ,获得积分10
26秒前
kid1912应助zhangxinting0818采纳,获得10
27秒前
一颗大白杨完成签到 ,获得积分10
28秒前
俭朴的大有完成签到,获得积分10
29秒前
羟醛缩合完成签到 ,获得积分10
29秒前
29秒前
wlp鹏发布了新的文献求助10
32秒前
我腹肌好疼完成签到,获得积分10
33秒前
37秒前
黎锦完成签到,获得积分20
40秒前
saberLee完成签到,获得积分10
41秒前
yuange发布了新的文献求助10
42秒前
今天没烦恼完成签到 ,获得积分10
48秒前
48秒前
住在魔仙堡的鱼完成签到 ,获得积分10
51秒前
一团小煤球完成签到,获得积分10
53秒前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
2-Acetyl-1-pyrroline: an important aroma component of cooked rice 500
A real-time energy management strategy based on fuzzy control and ECMS for PHEVs 400
Handbook on People's China (1957) 400
2024 Medicinal Chemistry Reviews 400
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3189706
求助须知:如何正确求助?哪些是违规求助? 2839050
关于积分的说明 8022625
捐赠科研通 2501914
什么是DOI,文献DOI怎么找? 1336060
科研通“疑难数据库(出版商)”最低求助积分说明 637770
邀请新用户注册赠送积分活动 605852