亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Differentiation of low- and high-grade pediatric gliomas with amide proton transfer imaging: added value beyond quantitative relaxation times

医学 接收机工作特性 神经组阅片室 胶质瘤 逻辑回归 曼惠特尼U检验 曲线下面积 核医学 逐步回归 多元分析 放射科 内科学 神经学 精神科 癌症研究
作者
Hongxi Zhang,Xingwang Yong,Xiaomeng Ma,Jun Zhao,Zhipeng Shen,Xinchun Chen,Feng-yu Tian,Weibo Chen,Dan Wu,Yi Zhang
出处
期刊:European Radiology [Springer Nature]
卷期号:31 (12): 9110-9119 被引量:12
标识
DOI:10.1007/s00330-021-08039-w
摘要

ObjectivesTo evaluate whether amide proton transfer (APT) MRI can be used to characterize gliomas in pediatric patients and whether it provides added value beyond relaxation times.MethodsIn this prospective study, APT imaging and relaxation time mapping were performed in 203 pediatric patients suspected of gliomas from February 2018 to December 2019. The region of interest (ROI) in the tumor was automatically generated with artifact detection and ROI-shrinking algorithms. Several APT-related metrics (CESTR, CESTRnr, MTRRex, AREX, and APT#) and quantitative T1 and T2 were compared between low-grade and high-grade gliomas using the student’s t-test or Mann-Whitney U-test. The performance of these parameters was assessed using the receiver operating characteristic (ROC) analysis. A stepwise multivariate logistic regression model was used to combine the imaging parameters.ResultsForty-eight patients (mean age: 6 ± 4 years; 23 males and 25 females) were included in the final analysis. All the APT-related metrics except APT# had significantly (p < 0.05) higher values in the high-grade group than the low-grade group. Under different ROI-shrinking cutoffs, the quantitative T1 (p = 0.045–0.200) and T2 (p = 0.037–0.171) values of high-grade gliomas were typically lower than those of low-grade ones. The stepwise multivariate logistic regression revealed that CESTRnr and APT# were combined significant predictors of glioma grades (p < 0.05), with an area under the ROC curve (AUC) of 0.86 substantially larger than those of T1 (AUC = 0.69) and T2 (AUC = 0.68).ConclusionsAPT imaging can be used to differentiate high-grade and low-grade gliomas in pediatric patients and provide added value beyond quantitative relaxation times.Key Points • Amide proton transfer (APT) MRI showed significantly (p < 0.05) higher values in pediatric patients with high-grade gliomas than those with low-grade ones. • The area under the curve was 0.86 for APT MRI to differentiate low-grade and high-grade gliomas in pediatric patients, which was substantially higher than that for quantitative T1 (0.69) and T2 (0.68). • APT MRI demonstrated added value beyond quantitative T1 and T2 mapping in characterizing pediatric gliomas.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
20秒前
20秒前
高兴小懒虫完成签到 ,获得积分10
25秒前
现代青枫应助高兴小懒虫采纳,获得10
1分钟前
1分钟前
2分钟前
gszy1975发布了新的文献求助80
3分钟前
3分钟前
DDX完成签到 ,获得积分10
4分钟前
gszy1975完成签到,获得积分10
4分钟前
风起云涌龙完成签到 ,获得积分0
4分钟前
有终完成签到 ,获得积分10
5分钟前
6分钟前
清净126完成签到 ,获得积分10
6分钟前
mellow完成签到,获得积分10
9分钟前
Nano-Su完成签到 ,获得积分10
11分钟前
rosalieshi应助芹菜采纳,获得30
11分钟前
owlhealth发布了新的文献求助10
11分钟前
现代青枫应助科研通管家采纳,获得10
12分钟前
12分钟前
13分钟前
liujunjie发布了新的文献求助10
13分钟前
zsmj23完成签到 ,获得积分0
13分钟前
14分钟前
所所应助杀了几只三七采纳,获得10
14分钟前
Orange应助科研通管家采纳,获得80
14分钟前
14分钟前
英姑应助Gaopkid采纳,获得10
14分钟前
Gaopkid完成签到,获得积分10
14分钟前
14分钟前
Gaopkid发布了新的文献求助10
15分钟前
15分钟前
现代青枫应助owlhealth采纳,获得10
15分钟前
现代青枫应助白华苍松采纳,获得10
15分钟前
15分钟前
16分钟前
不安萃发布了新的文献求助10
16分钟前
栗悟饭完成签到,获得积分10
16分钟前
不安萃完成签到,获得积分20
16分钟前
现代青枫应助白华苍松采纳,获得10
16分钟前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
Evolution 3rd edition 1500
保险藏宝图 1000
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 700
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 700
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3186712
求助须知:如何正确求助?哪些是违规求助? 2836935
关于积分的说明 8011948
捐赠科研通 2499373
什么是DOI,文献DOI怎么找? 1334305
科研通“疑难数据库(出版商)”最低求助积分说明 637154
邀请新用户注册赠送积分活动 605047