Differentiation of low- and high-grade pediatric gliomas with amide proton transfer imaging: added value beyond quantitative relaxation times

医学 接收机工作特性 神经组阅片室 胶质瘤 逻辑回归 曼惠特尼U检验 曲线下面积 核医学 逐步回归 多元分析 放射科 内科学 神经学 精神科 癌症研究
作者
Hongxi Zhang,Xingwang Yong,Xiaomeng Ma,Jun Zhao,Zhipeng Shen,Xinchun Chen,Feng-yu Tian,Weibo Chen,Dan Wu,Yi Zhang
出处
期刊:European Radiology [Springer Nature]
卷期号:31 (12): 9110-9119 被引量:12
标识
DOI:10.1007/s00330-021-08039-w
摘要

ObjectivesTo evaluate whether amide proton transfer (APT) MRI can be used to characterize gliomas in pediatric patients and whether it provides added value beyond relaxation times.MethodsIn this prospective study, APT imaging and relaxation time mapping were performed in 203 pediatric patients suspected of gliomas from February 2018 to December 2019. The region of interest (ROI) in the tumor was automatically generated with artifact detection and ROI-shrinking algorithms. Several APT-related metrics (CESTR, CESTRnr, MTRRex, AREX, and APT#) and quantitative T1 and T2 were compared between low-grade and high-grade gliomas using the student’s t-test or Mann-Whitney U-test. The performance of these parameters was assessed using the receiver operating characteristic (ROC) analysis. A stepwise multivariate logistic regression model was used to combine the imaging parameters.ResultsForty-eight patients (mean age: 6 ± 4 years; 23 males and 25 females) were included in the final analysis. All the APT-related metrics except APT# had significantly (p < 0.05) higher values in the high-grade group than the low-grade group. Under different ROI-shrinking cutoffs, the quantitative T1 (p = 0.045–0.200) and T2 (p = 0.037–0.171) values of high-grade gliomas were typically lower than those of low-grade ones. The stepwise multivariate logistic regression revealed that CESTRnr and APT# were combined significant predictors of glioma grades (p < 0.05), with an area under the ROC curve (AUC) of 0.86 substantially larger than those of T1 (AUC = 0.69) and T2 (AUC = 0.68).ConclusionsAPT imaging can be used to differentiate high-grade and low-grade gliomas in pediatric patients and provide added value beyond quantitative relaxation times.Key Points • Amide proton transfer (APT) MRI showed significantly (p < 0.05) higher values in pediatric patients with high-grade gliomas than those with low-grade ones. • The area under the curve was 0.86 for APT MRI to differentiate low-grade and high-grade gliomas in pediatric patients, which was substantially higher than that for quantitative T1 (0.69) and T2 (0.68). • APT MRI demonstrated added value beyond quantitative T1 and T2 mapping in characterizing pediatric gliomas.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
蛋挞完成签到 ,获得积分10
刚刚
Qiuyu完成签到 ,获得积分10
刚刚
weikeyan完成签到,获得积分10
刚刚
2秒前
yinying完成签到,获得积分10
4秒前
5秒前
6秒前
852应助乐悠采纳,获得10
7秒前
7秒前
8秒前
12366666完成签到,获得积分10
8秒前
9秒前
kento应助树袋熊采纳,获得100
9秒前
科研发布了新的文献求助10
11秒前
可爱非笑发布了新的文献求助10
13秒前
Elaine完成签到,获得积分10
13秒前
赘婿应助诸嵩采纳,获得10
15秒前
mang_er完成签到 ,获得积分10
16秒前
17秒前
顾城浪子发布了新的文献求助40
18秒前
科研完成签到,获得积分10
18秒前
自信的黑猫完成签到,获得积分10
18秒前
18秒前
19秒前
JOE_000000_完成签到,获得积分20
19秒前
panx发布了新的文献求助10
22秒前
噗噗发布了新的文献求助10
22秒前
斯文谷秋发布了新的文献求助10
22秒前
22秒前
刘wt发布了新的文献求助10
23秒前
SciGPT应助xixiz1024采纳,获得10
24秒前
25秒前
laymax完成签到,获得积分20
27秒前
彭于晏应助噗噗采纳,获得10
27秒前
赘婿应助飞飞采纳,获得10
27秒前
28秒前
Joanna发布了新的文献求助10
29秒前
云影清浅完成签到 ,获得积分10
29秒前
30秒前
31秒前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
ALA生合成不全マウスでの糖代謝異常の分子機構解析 520
Aspects of Babylonian celestial divination: the lunar eclipse tablets of Enūma Anu Enlil 500
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
2024 Medicinal Chemistry Reviews 400
Dictionary of socialism 350
Geochemistry, 2nd Edition 地球化学经典教科书第二版 300
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3193777
求助须知:如何正确求助?哪些是违规求助? 2842801
关于积分的说明 8041110
捐赠科研通 2506950
什么是DOI,文献DOI怎么找? 1339504
科研通“疑难数据库(出版商)”最低求助积分说明 638764
邀请新用户注册赠送积分活动 607589