Lactated Ringer’s Solution in Combination with Rectal Indomethacin for Prevention of Post-ERCP Pancreatitis: A Prospective Randomized, Double-Blinded, Controlled Trial

Aims Prospective data have shown the benefit of rectal indomethacin (IND) for preventing post-ERCP pancreatitis (PEP). Recents pilot studies demonstrated a lower incidence of PEP after an 8-hour lactated Ringer’s solution (LR) infusion. The aim of this study was to evaluate the efficacy of IND with or without bolus LR in patients at high-risk for PEP.