The application of decellularized human term fetal membranes in tissue engineering and regenerative medicine (TERM)

去细胞化 组织工程 再生医学 细胞外基质 再生(生物学) 纳米技术 干细胞 生物医学工程 细胞生物学 生物 材料科学 医学
作者
Aida Shakouri‐Motlagh,Ramin Khanabdali,Daniel E. Heath,Bill Kalionis
出处
期刊:Placenta [Elsevier]
卷期号:59: 124-130 被引量:26
标识
DOI:10.1016/j.placenta.2017.07.002
摘要

Tissue engineering and regenerative medicine (TERM) is a field that applies biology and engineering principles to “restore, maintain or repair a tissue after injury”. Besides the potential to treat various diseases, these endeavours increase our understanding of fundamental cell biology. Although TERM has progressed rapidly, engineering a whole organ is still beyond our skills, primarily due to the complexity of tissues. Material science and current manufacturing methods are not capable of mimicking this complexity. Therefore, many researchers explore the use of naturally derived materials that maintain important biochemical, structural and mechanical properties of tissues. Consequently, employing non-cellular components of tissues, particularly the extracellular matrix, has emerged as an alternative to synthetic materials. Because of their complexity, decellularized tissues are not as well defined as synthetic materials but they provide cells with a microenvironment that resembles their natural niche. Decellularized tissues are produced from a variety of sources, among which the fetal membranes are excellent candidates since their supply is virtually unlimited, they are readily accessible with minimum ethical concerns and are often discarded as a biological waste. In this review, we will discuss various applications of decellularized fetal membranes as substrates for the expansion of stem cells, their use as two and three-dimensional scaffolds for tissue regeneration, and their use as cell delivery systems. We conclude that fetal membranes have great potential for use in TERM.
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