ESCRT公司
内体
细胞生物学
自噬
溶酶体
生物
细胞内
生物化学
酶
细胞凋亡
作者
Michael L. Skowyra,Paul H. Schlesinger,Teresa V. Naismith,Phyllis I. Hanson
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2018-04-06
卷期号:360 (6384)
被引量:358
标识
DOI:10.1126/science.aar5078
摘要
Endolysosomes can be damaged by diverse materials. Terminally damaged compartments are degraded by lysophagy, but pathways that repair salvageable organelles are poorly understood. Here we found that the endosomal sorting complex required for transport (ESCRT) machinery, known to mediate budding and fission on endolysosomes, also plays an essential role in their repair. ESCRTs were rapidly recruited to acutely injured endolysosomes through a pathway requiring calcium and ESCRT-activating factors that was independent of lysophagy. We used live-cell imaging to demonstrate that ESCRTs responded to small perforations in endolysosomal membranes and enabled compartments to recover from limited damage. Silica crystals that disrupted endolysosomes also triggered ESCRT recruitment. ESCRTs thus provide a defense against endolysosomal damage likely to be relevant in physiological and pathological contexts.
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