免疫系统
获得性免疫系统
免疫
免疫学
信号转导
效应器
作者
Akihiko Yoshimura,Minako Ito,Shunsuke Chikuma,Takashi Akanuma,Hiroko Nakatsukasa
出处
期刊:Cold Spring Harbor Perspectives in Biology
[Cold Spring Harbor Laboratory]
日期:2017-07-17
卷期号:10 (7): a028571-a028571
被引量:116
标识
DOI:10.1101/cshperspect.a028571
摘要
Cytokines are key modulators of immunity. Most cytokines use the Janus kinase and signal transducers and activators of transcription (JAK-STAT) pathway to promote gene transcriptional regulation, but their signals must be attenuated by multiple mechanisms. These include the suppressors of cytokine signaling (SOCS) family of proteins, which represent a main negative regulation mechanism for the JAK-STAT pathway. Cytokine-inducible Src homology 2 (SH2)-containing protein (CIS), SOCS1, and SOCS3 proteins regulate cytokine signals that control the polarization of CD4+ T cells and the maturation of CD8+ T cells. SOCS proteins also regulate innate immune cells and are involved in tumorigenesis. This review summarizes recent progress on CIS, SOCS1, and SOCS3 in T cells and tumor immunity.
科研通智能强力驱动
Strongly Powered by AbleSci AI