Neurexin gene family variants as risk factors for autism spectrum disorder

神经鞘素 自闭症谱系障碍 自闭症 基因型 等位基因 遗传学 单核苷酸多态性 病因学 多态性(计算机科学) 等位基因频率 生物 基因 内科学 医学 精神科 突触后电位 受体
作者
Jia Wang,Jianhua Gong,Li Li,Yanlin Chen,Lingfei Liu,Huaiting Gu,Xiaobing Luo,Fang Hou,Jiajia Zhang,Ranran Song
出处
期刊:Autism Research [Wiley]
卷期号:11 (1): 37-43 被引量:58
标识
DOI:10.1002/aur.1881
摘要

Increasing evidence suggests that abnormal synaptic function leads to neuronal developmental disorders and is an important component of the etiology of autism spectrum disorder (ASD). Neurexins are presynaptic cell-adhesion molecules that affect the function of synapses and mediate the conduction of nerve signals. Thus, neurexins are attractive candidate genes for autism. Since gene families have greater power to reveal genetic association than single genes, we designed this case-control study to investigate six genetic variants in three neurexin genes (NRXN1, NRXN2, and NRXN3) in a Chinese population including 529 ASD patients and 1,923 healthy controls. We found that two SNPs were significantly associated with ASD after false discovery rate (FDR) adjustment for multiple comparisons. The NRXN2 rs12273892 polymorphism T allele and AT genotype were significantly associated with increased risk of ASD (respectively: OR = 1.328, 95% CI = 1.133-1.557, P < 0.001; OR = 1.528; 95% CI = 1.249-1.868, P < 0.001). The dominant model showed the same association (OR = 1.495, 95% CI = 1.231-1.816, P < 0.001). The NRXN3 rs12879016 polymorphism played a significant role in ASD susceptibility under the dominant model (OR = 0.747, 95% CI= 0.615-0.908, P = 0.023), with the same trend detected for the G allele and GT genotype (respectively: OR = 0.811, 95% CI = 0.699-0.941, P = 0.036; OR = 0.755, 95% CI = 0.615-0.928, P = 0.035). In conclusion, this study supports the importance of two genetic variants in the neurexin gene family in ASD susceptibility in China. Autism Res 2018, 11: 37-43. © 2017 International Society for Autism Research, Wiley Periodicals, Inc.Autism spectrum disorder (ASD) is a neurodevelopmental disorder that is highly heritable, and studies have found a number of candidate genes that might contribute to ASD. Neurexins are presynaptic cell-adhesion molecules that affect the function of synapses and mediate the conduction of nerve signals, and they play an important role in normal brain development and become candidate genes for autism. The purpose of our study is to explore the association between variants of the neurexins gene family and ASD in a Chinese population through a case-control study.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
YY完成签到 ,获得积分10
1秒前
领导范儿应助瞬间de回眸采纳,获得10
1秒前
小树叶完成签到,获得积分10
1秒前
zy_完成签到,获得积分10
1秒前
sea完成签到 ,获得积分10
2秒前
2秒前
研友_Z305k8完成签到,获得积分10
2秒前
清欢发布了新的文献求助10
3秒前
zigzag完成签到,获得积分10
3秒前
suyan完成签到 ,获得积分10
3秒前
吃菠萝的桃子完成签到 ,获得积分10
4秒前
zhang完成签到,获得积分10
4秒前
Jnest完成签到,获得积分10
4秒前
4秒前
Jojo发布了新的文献求助10
5秒前
石绿海完成签到,获得积分10
5秒前
5秒前
科研通AI2S应助jiafx采纳,获得10
5秒前
深情白风完成签到,获得积分20
6秒前
肥肠的枣糕啊完成签到,获得积分10
6秒前
无情鼠标完成签到,获得积分10
6秒前
wwww0wwww完成签到,获得积分10
6秒前
wyg117完成签到,获得积分10
6秒前
甜蜜的老五完成签到,获得积分10
6秒前
LI发布了新的文献求助20
6秒前
毓雅完成签到,获得积分10
6秒前
haohao完成签到,获得积分10
6秒前
CinBatt完成签到,获得积分10
7秒前
儒雅大白完成签到,获得积分10
7秒前
田様应助晓千晨采纳,获得10
7秒前
吉吉国王发布了新的文献求助10
7秒前
轻松的雪枫完成签到,获得积分10
8秒前
Jio完成签到,获得积分10
8秒前
无心的青寒完成签到,获得积分10
8秒前
星豆豆发布了新的文献求助30
8秒前
开心不评完成签到 ,获得积分10
9秒前
蕾丝花边牛爷爷完成签到,获得积分10
9秒前
9秒前
1111完成签到,获得积分10
10秒前
CO_Pro发布了新的文献求助10
10秒前
高分求助中
The late Devonian Standard Conodont Zonation 2000
Nickel superalloy market size, share, growth, trends, and forecast 2023-2030 2000
The Lali Section: An Excellent Reference Section for Upper - Devonian in South China 1500
Smart but Scattered: The Revolutionary Executive Skills Approach to Helping Kids Reach Their Potential (第二版) 1000
Very-high-order BVD Schemes Using β-variable THINC Method 850
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 800
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 800
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3249002
求助须知:如何正确求助?哪些是违规求助? 2892380
关于积分的说明 8271185
捐赠科研通 2560658
什么是DOI,文献DOI怎么找? 1389175
科研通“疑难数据库(出版商)”最低求助积分说明 651006
邀请新用户注册赠送积分活动 627869