磷酸蛋白质组学
蛋白质组学
仿形(计算机编程)
精密医学
计算机科学
数据科学
计算生物学
个性化医疗
系统生物学
数据集成
生物信息学
数据挖掘
医学
生物
病理
蛋白质磷酸化
蛋白激酶A
基因
操作系统
酶
生物化学
作者
Girolamo Giudice,Evangelia Petsalaki
摘要
Recent advances in proteomics allow the accurate measurement of abundances for thousands of proteins and phosphoproteins from multiple samples in parallel. Therefore, for the first time, we have the opportunity to measure the proteomic profiles of thousands of patient samples or disease model cell lines in a systematic way, to identify the precise underlying molecular mechanism and discover personalized biomarkers, networks and treatments. Here, we review examples of successful use of proteomics and phosphoproteomics data sets in as well as their integration other omics data sets with the aim of precision medicine. We will discuss the bioinformatics challenges posed by the generation, analysis and integration of such large data sets and present potential reasons why proteomics profiling and biomarkers are not currently widely used in the clinical setting. We will finally discuss ways to contribute to the better use of proteomics data in precision medicine and the clinical setting.
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