生物
血脑屏障
神经科学
发病机制
信号转导
神经血管束
疾病
电池类型
细胞
细胞生物学
中枢神经系统
免疫学
遗传学
病理
解剖
医学
作者
Zhen Zhao,Amy R. Nelson,Christer Betsholtz,Berislav V. Zloković
出处
期刊:Cell
[Elsevier]
日期:2015-11-01
卷期号:163 (5): 1064-1078
被引量:1267
标识
DOI:10.1016/j.cell.2015.10.067
摘要
Structural and functional brain connectivity, synaptic activity, and information processing require highly coordinated signal transduction between different cell types within the neurovascular unit and intact blood-brain barrier (BBB) functions. Here, we examine the mechanisms regulating the formation and maintenance of the BBB and functions of BBB-associated cell types. Furthermore, we discuss the growing evidence associating BBB breakdown with the pathogenesis of inherited monogenic neurological disorders and complex multifactorial diseases, including Alzheimer's disease.
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