表观遗传学
染色质
生物
转录因子
染色质重塑
调节器
计算生物学
癌症研究
遗传学
基因
作者
Nidhi Bansal,David Gourichon,Eduardo Farías,Samuel Waxman
出处
期刊:Advances in Cancer Research
日期:2016-01-01
卷期号:: 113-135
被引量:44
标识
DOI:10.1016/bs.acr.2016.01.006
摘要
Revolutionizing treatment strategies is an urgent clinical need in the fight against cancer. Recently the scientific community has recognized chromatin-associated proteins as promising therapeutic candidates. However, there is a need to develop more targeted epigenetic inhibitors with less toxicity. Sin3 family is one such target which consists of evolutionary conserved proteins with two paralogues Sin3A and Sin3B. Sin3A/B are global transcription regulators that provide a versatile platform for diverse chromatin-modifying activities. Sin3 proteins regulate key cellular functions that include cell cycle, proliferation, and differentiation, and have recently been implicated in cancer pathogenesis. In this chapter, we summarize the key concepts of Sin3 biology and elaborate the recent advancements in the role of Sin3 proteins in cancer with specific examples in multiple endocrine neoplasia type 2, pancreatic ductal adenocarcinoma, and triple negative breast cancer. Finally, a program to create an integrative approach for screening antitumor agents that target chromatin-associated factors like Sin3 is presented.
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