核小体
组蛋白密码
染色质
染色体
组蛋白H1
组蛋白
组蛋白八聚体
生物
计算生物学
遗传学
连接器DNA
组蛋白甲基化
细胞生物学
DNA
DNA甲基化
基因
基因表达
作者
Michael S. Cosgrove,Cynthia Wolberger
摘要
Patterns of histone post-translational modifications correlate with distinct chromosomal states that regulate access to DNA, leading to the histone-code hypothesis. However, it is not clear how modification of flexible histone tails leads to changes in nucleosome dynamics and, thus, chromatin structure. The recent discovery that, like the flexible histone tails, the structured globular domain of the nucleosome core particle is also extensively modified adds a new and exciting dimension to the histone-code hypothesis, and calls for the re-examination of current models for the epigenetic regulation of chromatin structure. Here, we review these findings and other recent studies that suggest the structured globular domain of the nucleosome core particle plays a key role regulating chromatin dynamics.Key words: histones, histone code, modifications, epigenetic, chromatin, nucleosome, dynamics, regulated nucleosome mobility, core, archaeal, combinatorial switch, histone octamer.
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