Development and Characterization of Poloxamer Solid Dispersions of Cefuroxime Axetil

The objective of the present investigation was to improve the dissolution rate of cefuroxime axetil, a BCS class-II drug by solid dispersion technique using a water soluble carrier, poloxamer 188(PXM). The solid dispersions were prepared by solvent evaporation method and the prepared systems showed an enhancement in dissolution. Solid dispersions characterized with Fourier transform infra red spectroscopy (FTIR) revealed no interaction between CA and poloxamer. Differential scanning calorimetry and X-ray diffraction revealed that the enhanced dissolution of CA from solid dispersion is due to a decrease in crystallinity of drug and additive and due to dissolution of cefuroxime axetil in the form of solid dispersion. In conclusion preparation of cefuroxime axetil dispersion with hydrophilic polymer could be a promising formulation approach to improve the dissolution rate.