Outcome variables in ankylosing spondylitis: evaluation of their relevance and discriminant capacity.

巴斯菲 医学 强直性脊柱炎 巴斯代人 物理疗法 脊柱炎 安慰剂 背痛 内科学 关节炎 病理 替代医学 银屑病性关节炎
作者
Andrei Călin,Nakache Jp,Antoine Guéguen,H. Zeidler,Herman Mielants,Maxime Dougados
出处
期刊:PubMed 卷期号:26 (4): 975-9 被引量:42
链接
标识
摘要

The clinical status of ankylosing spondylitis (AS) can be defined by several domains (e.g., pain, function, metrology, laboratory) and subcomponents within each domain (e.g., pain using visual analog scale, Schober's within metrology). Our aim was (1) To define groups of highly correlated variables in order to determine the most relevant; and (2) to evaluate the capacity of different clinical and biological variables that best discriminate between placebo and active nonsteroidal drugs in AS. Patients with active AS (n=423) were followed prospectively over 6 weeks while receiving placebo (n=121) or active nonsteroidal antiinflammatory drugs (n=352). Eighteen variables were studied, including global assessment, pain, stiffness, functional indices, metrology, disease activity index, and laboratory markers. Statistics included (1) Evaluation of the relevance of the different domains by multivariate analysis (CART tree-structure classification; variable clustering); and (2) evaluation of the discriminant capacity by univariate analysis [i.e., differences in the standardized response mean (SRM) (mean change/SD) between placebo and active drug. A value > or =0.60 was considered relevant]. Four clusters were identified (patient's subjective perception, inflammatory symptoms, metrology, laboratory data) with multiple correlation R2 revealing the most relevant variables to be the Bath Ankylosing Spondylitis Functional Index (BASFI; 0.75), night pain (0.62), Schober's test (0.58), and platelet count (0.55), respectively, within each cluster. In terms of discriminant power (SRM) the patient perceived global status (0.84), lumbar pain (0.73), night pain (0.71), physician global assessment (0.66), and BASFI (0.65) were most relevant in the univariate analysis. Among the 4 most relevant domains are subjective perception, inflammatory symptoms, metrology, and laboratory. Multivariate analysis of the data reveals that the spinal pain and the patient global assessment are the variables that best discriminate between placebo and active nonsteroidal drug in short term studies.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
Nayvue发布了新的文献求助10
3秒前
未来的幻想完成签到,获得积分10
5秒前
Kvolu29完成签到,获得积分10
6秒前
长理物电强完成签到,获得积分10
7秒前
若安在完成签到,获得积分10
8秒前
完美世界应助潘特采纳,获得10
9秒前
拼搏问薇完成签到 ,获得积分10
9秒前
单薄乐珍完成签到 ,获得积分0
12秒前
张静枝完成签到 ,获得积分10
12秒前
六步郎完成签到,获得积分10
12秒前
啊怙纲完成签到 ,获得积分10
14秒前
量子星尘发布了新的文献求助10
16秒前
scott_zip完成签到 ,获得积分10
17秒前
gxl完成签到,获得积分0
21秒前
xxx完成签到 ,获得积分10
24秒前
24秒前
努力生活的小柴完成签到,获得积分10
26秒前
28秒前
tangyong完成签到,获得积分10
30秒前
长安发布了新的文献求助10
30秒前
SucceedIn完成签到,获得积分10
31秒前
32秒前
35秒前
海洋岩土12138完成签到 ,获得积分10
36秒前
lzz完成签到 ,获得积分10
36秒前
冬雪完成签到,获得积分10
40秒前
woommoow完成签到,获得积分10
40秒前
aaatan完成签到 ,获得积分10
40秒前
lynn完成签到,获得积分10
41秒前
ABC发布了新的文献求助10
41秒前
回忆完成签到,获得积分10
42秒前
溜了溜了完成签到,获得积分10
45秒前
萧水白完成签到,获得积分10
47秒前
马桶盖盖子完成签到 ,获得积分10
47秒前
漆漆漆漆漆完成签到,获得积分10
49秒前
xzy998应助科研通管家采纳,获得10
49秒前
斯文败类应助科研通管家采纳,获得10
49秒前
天天快乐应助科研通管家采纳,获得10
49秒前
GB发布了新的文献求助30
49秒前
夜曦完成签到 ,获得积分0
51秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038184
求助须知:如何正确求助?哪些是违规求助? 3575908
关于积分的说明 11373872
捐赠科研通 3305715
什么是DOI,文献DOI怎么找? 1819255
邀请新用户注册赠送积分活动 892662
科研通“疑难数据库(出版商)”最低求助积分说明 815022