钠通道
钙
毒液
钾通道
电压依赖性钙通道
化学
毒素
生物物理学
心肌
钙通道
钾
钠
生物化学
生物
内分泌学
有机化学
作者
Alison Brown,Atsuko Yatani,Lacerda Ae,Gurrola Gb,Possani Ld
摘要
We searched for and found a toxin that acts specifically on cardiac calcium channels. This toxin, which we have designated TaiCatoxin (TCX), was purified from the venom of the Australian Taipan snake (Oxyuranus s. scutellatus), one of the world's most poisonous snakes. TCX is a highly charged, basic polypeptide with a molecular weight of 8,000. It blocks high- but not low-threshold cardiac calcium channels in a voltage-dependent manner and has no effect on potassium or sodium channels. The block occurs at nanomolar concentrations, is reversible, and is due to binding at an extracellularly facing site on the channel itself.
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