A High‐Performance Ytterbium‐Based Nanoparticulate Contrast Agent for In Vivo X‐Ray Computed Tomography Imaging

Angewandte ChemieVolume 124, Issue 6 p. 1466-1471 Zuschrift A High-Performance Ytterbium-Based Nanoparticulate Contrast Agent for In Vivo X-Ray Computed Tomography Imaging† Yanlan Liu, Yanlan Liu State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun 130022 (P.R. China)Search for more papers by this authorKelong Ai, Kelong Ai State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun 130022 (P.R. China)Search for more papers by this authorJianhua Liu, Jianhua Liu Department of Radiology, the Second Hospital of Jilin University Norman Bethune, Changchun, 130022 (P.R. China)Search for more papers by this authorProf. Qinghai Yuan, Prof. Qinghai Yuan Department of Radiology, the Second Hospital of Jilin University Norman Bethune, Changchun, 130022 (P.R. China)Search for more papers by this authorYangyang He, Yangyang He Department of Pathology, the Second Hospital of Jilin University Norman Bethune, Changchun, 130022 (P.R. China)Search for more papers by this authorProf. Lehui Lu, Corresponding Author Prof. Lehui Lu lehuilu@ciac.jl.cn State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun 130022 (P.R. China)State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun 130022 (P.R. China)Search for more papers by this author Yanlan Liu, Yanlan Liu State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun 130022 (P.R. China)Search for more papers by this authorKelong Ai, Kelong Ai State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun 130022 (P.R. China)Search for more papers by this authorJianhua Liu, Jianhua Liu Department of Radiology, the Second Hospital of Jilin University Norman Bethune, Changchun, 130022 (P.R. China)Search for more papers by this authorProf. Qinghai Yuan, Prof. Qinghai Yuan Department of Radiology, the Second Hospital of Jilin University Norman Bethune, Changchun, 130022 (P.R. China)Search for more papers by this authorYangyang He, Yangyang He Department of Pathology, the Second Hospital of Jilin University Norman Bethune, Changchun, 130022 (P.R. China)Search for more papers by this authorProf. Lehui Lu, Corresponding Author Prof. Lehui Lu lehuilu@ciac.jl.cn State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun 130022 (P.R. China)State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun 130022 (P.R. China)Search for more papers by this author First published: 30 December 2011 https://doi.org/10.1002/ange.201106686Citations: 16 † Financial support by NSFC (Nos. 21125521, 21075117), the National Basic Research Program of China (973 Program, No. 2010CB933600), and the "Hundred Talents Project" of the Chinese Academy of Science is gratefully acknowledged. Read the full textAboutPDF ToolsRequest permissionAdd to favorites ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Erleuchtende Partikel: Ein neues Kontrastmittel für die Röntgen-Computertomographie (CT) besteht aus einem ytterbiumbasierten Nanopartikel (NP), das mit Ölsäure stabilisiert und mit dem biokompatiblen Polymer DSPE-PEG 2000 modifiziert ist (siehe Bild). Das Kontrastmittel zeigt eine lange Zirkulationszeit in vivo, ist wenig toxisch und effizienter als ein klinisch eingesetztes iodiertes Agens. Citing Literature Supporting Information Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Filename Description ange_201106686_sm_miscellaneous_information.pdf1.9 MB miscellaneous_information Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume124, Issue6February 6, 2012Pages 1466-1471 This is the German version of Angewandte Chemie. Note for articles published since 1962: Do not cite this version alone. Take me to the International Edition version with citable page numbers, DOI, and citation export. We apologize for the inconvenience. RelatedInformation