MECHANISMS OF THE FORMATION OF MOTOR-SECRETORY DISORDERS IN PATIENTS WITH GERD WITH CONCOMITANT AIT

The aim: The aim of this work was to study the effect of thyroid hormones on motor-secretory dysfunction in patients with GERD with concomitant AIT. Materials and methods: The study involved three groups of patients: with isolated GERD, GERD with AIT at the stage of hypothyroidism and GERD with AIT at the stage of hyperthyroidism. The control group consisted of 15 practically healthy individuals. GERD and AIT were diagnosed on the basis of ICD-10. All patients underwent a comprehensive examination, including ultrasound examination of the motor-evacuation function of the esophagus and stomach. Quality of life of patients was assessed by using the GIQLI questionnaire. Results: The most expressed complaints and low quality of life are observed among patients with combined pathology. The results of pH-metry indicate more severe course of GERD among patients with concomitant AIT. The most pronounced decrease in the tone of the lower esophageal sphincter and increased regurgitation were observed in the second group. Conclusions: 1. It was found that more reliable motor-secretory disorders were observed among patients with GERD with concomitant AIT. 2. A close correlation was established between the severity of the clinical picture, the level of increased thyroid hormones and the degree of impairment of motor-secretory disorders among patients with GERD with concomitant AIT; 3. The results obtained indicate that changes in the metabolism of thyroid hormones are one of the factors involved in the mechanisms of GERD formation.