Targeting Virus-Induced Reprogrammed Cell Metabolism via Glycolytic Inhibitors: An Effective Therapeutic Approach Against SARS-CoV-2

细胞代谢 细胞代谢 生物 病毒 病毒复制 新陈代谢 背景(考古学) 细胞 病毒病机 病毒学 细胞生物学 生物化学 古生物学
作者
Mamta Singh,Dolly Sharma,Rajat Gupta,Manoj Garg,Andrea Altieri,Alexander V. Kurkin,Vinit Kumar,Reshma Rani
出处
期刊:Mini-reviews in Medicinal Chemistry [Bentham Science]
卷期号:23 (2): 120-130 被引量:1
标识
DOI:10.2174/1389557522666220616112042
摘要

Abstract: Reprogrammed cell metabolism has been observed in a wide range of virally infected cells. Viruses do not have their metabolism; they rely on the cellular metabolism of the host to ensure the energy and macromolecules requirement for replication. Like other viruses, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) does not own its metabolism, but virus infected cells adopt aberrant cell metabolism. Infected viral use the energy and macromolecules to make their own copies; to do so, they need to increase the rate of metabolism to ensure the requirement of macromolecules. In contrast, the cellular metabolism of noninfected cells is more plastic than infected cells. Therefore, it is essential to examine the virus infection in the context of metabolic alterations of host cells. A novel therapeutic approach is urgently required to treat highly infectious COVID-19 disease and its pathogenesis. Interference of glucose metabolism might be a promising strategy to determine COVID-19 treatment options. Based on the recent research, this mini-review aims to understand the impact of reprogrammed cell metabolism in COVID-19 pathogenesis and explores the potential of targeting metabolic pathways with small molecules as a new strategy for the development of a novel drug to treat COVID-19 disease. This type of research line provides new hope in the development of antiviral drugs by targeting hijacked cell metabolism in case of viral diseases and also in COVID-19.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
小二郎应助生动的战斗机采纳,获得10
1秒前
2秒前
林秋沐发布了新的文献求助10
2秒前
十七完成签到 ,获得积分10
2秒前
怡然可乐完成签到,获得积分10
3秒前
ding应助小书包采纳,获得10
3秒前
我是老大应助犹豫酸奶采纳,获得10
4秒前
4秒前
Serena510完成签到 ,获得积分10
4秒前
5秒前
5秒前
5秒前
xiaoli发布了新的文献求助100
6秒前
6秒前
6秒前
gggja完成签到,获得积分10
6秒前
7秒前
zhuxinxin发布了新的文献求助10
7秒前
隐形曼青应助要吃烧饼么采纳,获得10
7秒前
7秒前
7秒前
jambo_y完成签到,获得积分10
7秒前
Yuzuruyan完成签到,获得积分10
8秒前
天天快乐应助Re采纳,获得10
9秒前
NexusExplorer应助愉快的夏柳采纳,获得10
9秒前
bluesky发布了新的文献求助10
9秒前
sunsunsun发布了新的文献求助10
9秒前
1rd完成签到,获得积分20
9秒前
9秒前
9秒前
10秒前
轻松的天真完成签到,获得积分10
10秒前
10秒前
qwertuyo发布了新的文献求助10
11秒前
11秒前
别闹闹发布了新的文献求助10
11秒前
红红酱发布了新的文献求助10
11秒前
初七123发布了新的文献求助10
12秒前
所所应助zhengyang采纳,获得10
12秒前
高分求助中
Sustainability in ’Tides Chemistry 2000
The ACS Guide to Scholarly Communication 2000
Studien zur Ideengeschichte der Gesetzgebung 1000
TM 5-855-1(Fundamentals of protective design for conventional weapons) 1000
Threaded Harmony: A Sustainable Approach to Fashion 810
Handbook of the Mammals of the World – Volume 3: Primates 805
Ethnicities: Media, Health, and Coping 800
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3073445
求助须知:如何正确求助?哪些是违规求助? 2727003
关于积分的说明 7497465
捐赠科研通 2375088
什么是DOI,文献DOI怎么找? 1259304
科研通“疑难数据库(出版商)”最低求助积分说明 610574
版权声明 597075