狼牙棒
氯吡格雷
CYP2C19型
经皮冠状动脉介入治疗
医学
内科学
传统PCI
急性冠脉综合征
优势比
阿司匹林
置信区间
逻辑回归
心脏病学
人口
心肌梗塞
细胞色素P450
环境卫生
新陈代谢
作者
Tingting Wang,Jie Feng,Lei Zhou,Ting Zhao,Huilan Zhang,Hao Shen,Li Xu,Li Sun,Jihuai Wu,Hongjian Li,Luhai Yu
出处
期刊:Endocrine, metabolic & immune disorders
[Bentham Science]
日期:2023-01-01
卷期号:23 (2): 196-204
标识
DOI:10.2174/1871530322666220523142229
摘要
Clopidogrel activity is influenced by cytochrome P450 (CYP450). CYP2C19 polymorphisms vary by ethnicity and region.The aim of the study is to assess the effect of genetic polymorphisms in CYP2C19*2 and *3 and clinical and demographic factors on major adverse cardiovascular events (MACE) in Kazak patients following percutaneous coronary intervention (PCI).397 patients with PCI treated with clopidogrel and aspirin for at least 12 months were enrolled and outcomes within 1 year were recorded. Approximately 2 ml of peripheral venous blood samples were used for genotype detection. Multivariable logistic regression analyses were performed to identify factors associated with MACE.95 patients (23.9%) suffered MACE during the period. Logistic regression analysis revealed CYP2C19*2 carriers (odds ratio [OR]: 2.431, 95% [confidence interval] CI: 1.136- 5.275, P = 0.027) and poor metabolizers (OR: 2.128, 95% CI: 0.899-4.82, P = 0.043) to be significantly associated with MACE.The CYP2C19*2 allele variants and poor metabolizers were found to be associated with MACE in a clopidogrel-treated Kazak population with acute coronary syndrome following PCI.
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