Brain Cell Senescence: A New Therapeutic Target for the Acute Treatment of Ischemic Stroke

衰老 脂褐素 医学 缺血 冲程(发动机) 内科学 病理 内分泌学 机械工程 工程类
作者
Júlia Baixauli-Martín,Alicia Aliena-Valero,María Castelló-Ruiz,María C Burguete,Mikahela A López-Morales,Daniel Muñoz-Espín,Germán Torregrosa,Juan B Salom
出处
期刊:Journal of Neuropathology and Experimental Neurology [Oxford University Press]
卷期号:81 (8): 614-620 被引量:2
标识
DOI:10.1093/jnen/nlac048
摘要

Abstract Aging is a major risk factor for cerebral infarction. Since cellular senescence is intrinsic to aging, we postulated that stroke-induced cellular senescence might contribute to neural dysfunction. Adult male Wistar rats underwent 60-minute middle cerebral artery occlusion and were grouped according to 3 reperfusion times: 24 hours, 3, and 7 days. The major biomarkers of senescence: 1) accumulation of the lysosomal pigment, lipofuscin; 2) expression of the cell cycle arrest markers p21, p53, and p16INK4a; and 3) expression of the senescence-associated secretory phenotype cytokines interleukin-6 (IL-6), tumor necrosis factor α (TNF-α), and interleukin-1β (IL-1β) were investigated in brain samples. Lipofuscin accumulation was scarce at the initial stage of brain damage (24 hours), but progressively increased until it reached massive distribution at 7 days post-ischemia. Lipofuscin granules (aggresomes) were mainly confined to the infarcted areas, that is parietal cortex and adjacent caudate-putamen, which were equally affected. The expression of p21, p53, and p16INK4a, and that of IL-6, TNF-α, and IL-1β, was significantly higher in the ischemic hemisphere than in the non-ischemic hemisphere. These data indicate that brain cell senescence develops during acute ischemic infarction and suggest that the acute treatment of ischemic stroke might be enhanced using senolytic drugs.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
CipherSage应助zzzyyyuuu采纳,获得10
刚刚
刚刚
李健的小迷弟应助张鑫采纳,获得30
刚刚
1秒前
2秒前
搜集达人应助CJW采纳,获得10
2秒前
pryturk发布了新的文献求助10
3秒前
宇哥发布了新的文献求助10
3秒前
jiaxin发布了新的文献求助10
3秒前
6秒前
6秒前
7秒前
7秒前
Grace0610完成签到,获得积分20
8秒前
8秒前
8秒前
xiao123789发布了新的文献求助10
9秒前
饱满秋完成签到,获得积分10
9秒前
自信号厂完成签到 ,获得积分10
10秒前
CHH发布了新的文献求助10
10秒前
陶治发布了新的文献求助10
11秒前
张鑫发布了新的文献求助30
12秒前
Grace0610发布了新的文献求助10
12秒前
yutang完成签到 ,获得积分10
12秒前
张菁完成签到,获得积分10
12秒前
pryturk完成签到,获得积分10
13秒前
13秒前
13秒前
13秒前
项德胜完成签到,获得积分10
14秒前
jiaxin完成签到,获得积分10
14秒前
帅发发布了新的文献求助10
16秒前
科研通AI2S应助houl采纳,获得10
16秒前
深情安青应助iWanted采纳,获得10
16秒前
自觉平露完成签到,获得积分10
16秒前
张鑫完成签到,获得积分10
17秒前
Leohp完成签到,获得积分10
18秒前
Allen完成签到,获得积分10
18秒前
Ava应助宇哥采纳,获得10
19秒前
linjiaxin完成签到,获得积分10
20秒前
高分求助中
The Oxford Handbook of Social Cognition (Second Edition, 2024) 1050
Kinetics of the Esterification Between 2-[(4-hydroxybutoxy)carbonyl] Benzoic Acid with 1,4-Butanediol: Tetrabutyl Orthotitanate as Catalyst 1000
The Young builders of New china : the visit of the delegation of the WFDY to the Chinese People's Republic 1000
юрские динозавры восточного забайкалья 800
English Wealden Fossils 700
Handbook of Qualitative Cross-Cultural Research Methods 600
Chen Hansheng: China’s Last Romantic Revolutionary 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3140111
求助须知:如何正确求助?哪些是违规求助? 2790982
关于积分的说明 7797203
捐赠科研通 2447324
什么是DOI,文献DOI怎么找? 1301841
科研通“疑难数据库(出版商)”最低求助积分说明 626345
版权声明 601194