鲁米诺
电化学发光
化学
光化学
阴极保护
电化学
Atom(片上系统)
化学发光
电极
物理化学
嵌入式系统
计算机科学
作者
Wenling Gu,Xiaosi Wang,Mengzhen Xi,Xiaoqian Wei,Lei Jiao,Ying Qin,Jiajia Huang,Xiaowen Cui,Lirong Zheng,Liuyong Hu,Chengzhou Zhu
标识
DOI:10.1021/acs.analchem.2c01794
摘要
The conventional cathodic electrochemiluminescence (ECL) always requires a more negative potential to trigger strong emission, which inevitably damages the bioactivity of targets and decreases the sensitivity and specificity. In this work, iron single-atom catalysts (Fe-N-C SACs) were employed as an efficient co-reaction accelerator for the first time to achieve the impressively cathodic emission of a luminol-H2O2 ECL system at an ultralow potential. Benefiting from the distinct electronic structure, Fe-N-C SACs exhibit remarkable properties for the activation of H2O2 to produce massive reactive oxygen species (ROS) under a negative scanning potential from 0 to -0.2 V. The ROS can oxidize the luminol anions into luminol anion radicals, avoiding the tedious electrochemical oxidation process of luminol. Then, the in situ-formed luminol anion radicals will directly react with ROS for the strong ECL emission. As a proof of concept, sensitive detection of the carcinoembryonic antigen was realized by glucose oxidase-mediated ECL immunoassay, shedding light on the superiority of SACs to construct efficient cathodic ECL systems with low triggering potential.
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