蓝斑
PSEN1型
楔前
神经科学
阿尔茨海默病
医学
β淀粉样蛋白
神经影像学
磁共振成像
疾病
认知功能衰退
病理
早老素
心理学
痴呆
认知
中枢神经系统
放射科
作者
Heidi I.L. Jacobs,J. Alex Becker,Kenneth K. Kwong,Diana Munera,Liliana Ramı́rez-Gomez,Nina Engels,Justin S. Sanchez,Clara Vila‐Castelar,Ana Baena,Reisa A. Sperling,Keith A. Johnson,Francisco Lopera,Yakeel T. Quiroz
摘要
Abstract Introduction Autopsy studies recognize the locus coeruleus (LC) as one of the first sites accumulating tau in Alzheimer's disease (AD). Recent AD work related in vivo LC magnetic resonance imaging (MRI) integrity to tau and cognitive decline; however, relationships of LC integrity to age, tau, and cognition in autosomal dominant AD (ADAD) remain unexplored. Methods We associated LC integrity (3T‐MRI) with estimated years of onset, cortical amyloid beta, regional tau (positron emission tomography [PET]) and memory (Consortium to Establish a Registry for Alzheimer's Disease (CERAD) Word‐List‐Learning) among 27 carriers and 27 non‐carriers of the presenilin‐1 ( PSEN1 ) E280A mutation. Longitudinal changes between LC integrity and tau were evaluated in 10 carriers. Results LC integrity started to decline at age 32 in carriers, 12 years before clinical onset, and 20 years earlier than in sporadic AD. LC integrity was negatively associated with cortical tau, independent of amyloid beta, and predicted precuneus tau increases. LC integrity was positively associated with memory. Discussion These findings support LC integrity as marker of disease progression in preclinical ADAD.
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