趋磁细菌
磁小体
磁热疗
体内
磁性纳米粒子
材料科学
纳米技术
体外
纳米生物技术
细菌
生物物理学
磁场
生物
纳米颗粒
磁铁矿
生物化学
生物技术
物理
遗传学
量子力学
冶金
作者
Changyou Chen,Pingping Wang,Haitao Chen,Xue Wang,Malka N. Halgamuge,Chuanfang Chen,Tao Song
标识
DOI:10.1021/acsami.1c24154
摘要
Magnetotactic bacteria are ubiquitous microorganisms in nature that synthesize intracellular magnetic nanoparticles called magnetosomes in a gene-controlled way and arrange them in chains. From in vitro to in vivo, we demonstrate that the intact body of Magnetospirillum magneticum AMB-1 has potential as a natural magnetic hyperthermia material for cancer therapy. Compared to chains of magnetosomes and individual magnetosomes, the entire AMB-1 cell exhibits superior heating capability under an alternating magnetic field. When incubating with tumor cells, the intact AMB-1 cells disperse better than the other two types of magnetosomes, decreasing cellular viability under the control of an alternating magnetic field. Furthermore, in vivo experiments in nude mice with neuroblastoma found that intact AMB-1 cells had the best antitumor activity with magnetic hyperthermia therapy compared to other treatment groups. These findings suggest that the intact body of magnetotactic bacteria has enormous promise as a natural material for tumor magnetic hyperthermia. In biomedical applications, intact and living magnetotactic bacteria play an increasingly essential function as a targeting robot due to their magnetotaxis.
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