材料科学
微电极
佩多:嘘
小型化
导电聚合物
生物医学工程
纳米技术
聚苯乙烯磺酸盐
脑植入物
聚合物
电极
涂层
信号(编程语言)
电阻抗
多电极阵列
甲基丙烯酸酯
光电子学
聚合
电气工程
复合材料
计算机科学
工程类
物理化学
医学
化学
程序设计语言
作者
Gary Kwok Ki Chik,Na Xiao,Xudong Ji,Anderson Chun On Tsang,Gkk Leung,Shiming Zhang,Chung Tin,Paddy K. L. Chan
标识
DOI:10.1002/admt.202200143
摘要
Abstract Miniaturization and minimization of mechanical mismatch in neural probes have been two well‐proven directions in suppressing immune response and improving spatial resolution for neuronal stimulations and recordings. While the high impedance brought by the miniaturization of electrodes has been addressed by using conductive polymers coatings in multiple reports, the stiffness of such coatings remains orders of magnitude higher than that of the brain tissue. Here, a flat neural probe based on a highly flexible microelectrode array with electrodeposited hydrogel coatings poly(2‐hydroxyethyl methacrylate) (pHEMA) and conductive polymer poly(3,4‐ethylenedioxythiophene) polystyrene sulfonate (PEDOT/PSS), with a cross‐section area at only 300 µ m × 2.5 µ m is presented. The PEDOT/PSS coating provides a low interfacial impedance, and the pHEMA deposition bridges the mechanical mismatch between the probe and the brain tissues. The two layers of polymers modification enhance the signal‐to‐noise ratio and allow the microelectrodes array to be engineered for both recording and stimulation purposes. Besides, in vivo testing of microelectrode arrays implanted in rat hippocampus confirms a high senstivity in neural signal recording and excellent charge injection capacity which can induce long‐term potentiation in neural activities in the hippocampus. The probes provide a robust and low‐cost solution to the brain interfaces problem.
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