Improving insights into the heterogeneous HFpEF syndrome through microvascular research

In the past few years, basic, translational and clinical research in heart failure with preserved ejection fraction (HFpEF) has intensified while patient numbers rise [1]. The search for effective treatments parallels the search for a better understanding of the pathophysiological mechanisms driving HFpEF. We address limitations regarding the suggested central role of microvascular dysfunction (MVD) in HFpEF and suggest a translational approach to bridge knowledge gaps therein.