Application of electrochemical sensors based on nanomaterials modifiers in the determination of antipsychotics

At present, the content of antipsychotics in samples is always analyzed by traditional detection methods, including mass spectrometry (MS), spectrophotometry, fluorescence, capillary electrophoresis (CE). However, conventional methods are cumbersome and complex, require a large sample volume, many pre-processing steps, long analysis cycles, expensive instruments, and need well-trained detection capabilities personnel. In addition, patients with schizophrenia require frequent and painful blood collection procedures, which adds additional treatment costs and time burdens. In view of these factors, electrochemical methods have become the most promising candidate technology for timely analysis due to their low cost, simple operation, excellent sensitivity and specificity. As we all know, nanomaterials play an extremely important role in electrochemical sensing applications. As the sensor modifiers, nanomaterials enable electrochemical analysis to overcome the time-consuming and labor-intensive shortcomings of traditional detection methods, and greatly reduce the research cost. Nanomaterials modified electrodes can be used as sensors to determine the concentration of antipsychotics in organisms quickly and accurately, which is a bright spot in the application of nanomaterials. The combination of different nanomaterials can even form a nanocomposite with a synergistic effect. This paper firstly reviews the application of nanomaterials-modified sensors on the basis of research in the past ten years, reviews the use of nanomaterial-modified sensors to quickly and accurately determine the concentration of antipsychotics in biological samples, and demonstrates a new idea of using nanomaterials sensors for drug monitoring and determination. At the end of this review, a brief overview is given of the limitations and the future prospects of nanomaterial sensors for the determination of antipsychotics concentrations.