医学
闭塞性细支气管炎
疾病
肺炎
病理
闭塞性细支气管炎机化性肺炎
介绍(产科)
毛细支气管炎
吸入性肺炎
放射科
结缔组织病
结缔组织
隐源性机化性肺炎
肺
解剖
呼吸系统
内科学
肺移植
自身免疫性疾病
作者
Sujith V. Cherian,Dhara Patel,Stephen Machnicki,David P. Naidich,Diane E. Stover,William D. Travis,Kevin K. Brown,Jason J. Naidich,Akhilesh Mahajan,Michael Esposito,Bushra Mina,Viera Lakticova,Stuart L. Cohen,Néstor L. Müller,Jenna Schulner,Matthew Bacchetta,Suhail Raoof
出处
期刊:Chest
[Elsevier]
日期:2022-01-14
卷期号:162 (1): 156-178
被引量:29
标识
DOI:10.1016/j.chest.2021.12.659
摘要
Organizing pneumonia (OP), characterized histopathologically by patchy filling of alveoli and bronchioles by loose plugs of connective tissue, may be seen in a variety of conditions. These include but are not limited to after an infection, drug reactions, radiation therapy, and collagen vascular diseases. When a specific cause is responsible for this entity, it is referred to as "secondary OP." When an extensive search fails to reveal a cause, it is referred to as "cryptogenic OP" (previously called "bronchiolitis obliterans with OP"), which is a clinical, radiologic, and pathologic entity classified as an interstitial lung disease. The clinical presentation of OP often mimics that of other disorders, such as infection and cancer, which can result in a delay in diagnosis and inappropriate management of the underlying disease. The radiographic presentation of OP is polymorphous but often has subpleural consolidations with air bronchograms or solitary or multiple nodules, which can wax and wane. Diagnosis of OP sometimes requires histopathologic confirmation and exclusion of other possible causes. Treatment usually requires a prolonged steroid course, and disease relapse is common. The aim of this article is to summarize the clinical, radiographic, and histologic presentations of this disease and to provide a practical diagnostic algorithmic approach incorporating clinical history and characteristic imaging patterns.
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