光热治疗
生物相容性
光热效应
谷胱甘肽
纳米材料
化学
催化作用
纳米技术
锰
材料科学
生物物理学
酶
生物化学
有机化学
生物
作者
Ruoxi Zhao,Yanlin Zhu,Jialing Zhou,Bin Liu,Yaqian Du,Shili Gai,Ruifang Shen,Lili Feng,Piaoping Yang
出处
期刊:ACS Nano
[American Chemical Society]
日期:2022-07-07
卷期号:16 (7): 10904-10917
被引量:35
标识
DOI:10.1021/acsnano.2c03222
摘要
Semimetallic nanomaterials as photothermal agents for bioimaging and cancer therapy have attracted tremendous interest. However, the poor photothermal stability, low biocompatibility, and single component limit their therapeutic efficiency in cancer treatment. Here, manganese-doped VSe2 semimetallic nanosheets were prepared and subsequently modified with chitosan (named VSe2/Mn-CS NSs) for combined enzyme catalytic and photothermal therapy. VSe2/Mn-CS NSs show high photothermal property with a photothermal conversion efficiency of 34.61% upon 808 nm near-infrared laser irradiation. In the tumor microenvironment, VSe2/Mn-CS NSs can convert endogenous H2O2 into lethal hydroxyl radicals (•OH) to induce cancer cell apoptosis. The interaction between glutathione (GSH) and Se–Se bonds in VSe2/Mn-CS NSs results in the depletion of GSH level, and the valence states transition of manganese ions is also beneficial for the GSH consumption. This dual depletion of GSH markedly enhances the peroxidase (POD) activity, leading to the high •OH production and the improved therapeutic effect. What is more, the T1-weighted magnetic resonance and photoacoustic imaging endow VSe2/Mn-CS NSs with the ability to guide and track the treatment process. Our study provides a research strategy for the application of semimetallic nanomaterials in cancer diagnosis and treatment.
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