Effect of Central Corneal Thickness on Corneal Higher Order Aberrations After Cataract Surgery

To investigate the changes of corneal higher order aberrations (HOAs) before and after phacoemulsification in patients with different central corneal thickness (CCT).In this retrospective non-randomized, non- comparative cases series, 51 eyes of 51 patients who underwent phacoemulsification were enrolled. The corneal total HOAs and Zernike coefficients (3rd and 4th order) over the 3- and 4-mm zones were measured by the iTrace aberrometer (Tracey Technologies). Participants were divided into three groups (528 µm or less, 529 to 550 µm, and greater than 550 µm) depending on the CCT tested by the LenStar LS900 (Haag Streit AG). The corneal aberrations between groups were compared with analysis of variance, the variation of corneal aberrations before and after phacoemulsification was analyzed by the paired-samples t test, and generalized linear models were used to compare postoperative aberrations between groups.Significant differences were found in oblique trefoil at 3 mm and vertical trefoil, oblique trefoil, and HOAs at 4 mm in the 528 µm or less group; vertical trefoil, oblique trefoil, oblique quadrafoil, and oblique secondary astigmatism at 3 mm and oblique trefoil and oblique secondary astigmatism at 4 mm in the 529 to 550 µm group; and vertical quadrafoil at 3 mm in the greater than 550 µm group. After corrected deviation of preoperative aberrations, there were significant differences in postoperative vertical coma and oblique secondary astigmatism at 4 mm when compared to the 528 µm or less and greater than 550 µm groups.The lower the CCT, the greater the change in corneal aberrations in patients with cataract after phacoemulsification. Surgeons should be aware of the potential for worse visual quality related to surgically induced aberrations in patients with thin corneas. [J Refract Surg. 2021;37(12):842-847.].