Copper‐Catalyzed Multicomponent Oxysulfonylation of Alkenes with Cyclobutanone Oxime Esters and Hydroxamic Acids via the Insertion of Sulfur Dioxide

Abstract A copper‐catalyzed multicomponent oxysulfonylation of alkenes with cyclobutanone oxime esters and hydroxamic acids via the insertion of sulfur dioxide has been developed. This reaction uses K 2 S 2 O 5 as the sulfur dioxide surrogate and the in situ generated amidoxyl radical as radical interceptor, thus providing a direct approach to β‐amidoxy sulfones in 35–90% yields. Mechanistic studies revealed that a radical‐radical coupling reaction of the alkyl radical and amidoxyl radical might be involved in this transformation. magnified image