Prolonged Ovarian Stimulation Does Not Worsen Neonatal Outcomes After Fresh Embryo Transfers

医学 倾向得分匹配 优势比 胎龄 置信区间 回顾性队列研究 胚胎移植 活产 产科 人口 出生体重 怀孕 内科学 生物 遗传学 环境卫生
作者
Jing Wu,Ying Ju,Jie Dong,Hengde Zhang,Xifeng Xiao,Xiaohong Wang
出处
期刊:Bjog: An International Journal Of Obstetrics And Gynaecology [Wiley]
被引量:1
标识
DOI:10.1111/1471-0528.18062
摘要

ABSTRACT Objective To investigate the relationship between prolonged ovarian stimulation and neonatal outcomes after autologous fresh embryo transfer (fET). Design A retrospective cohort study. Setting University‐affiliated centres. Population 3529 patients underwent autologous in vitro fertilisation (IVF) cycles between August 1, 2016 and December 31, 2022, with a live singleton birth after fET. Methods Univariate and multivariate regression analyses were used to determine the relationship between prolonged ovarian stimulation and neonatal outcomes. Propensity score matching (PSM) was applied to evaluate independent effects. Main Outcome Measures Neonatal outcomes. Results Multivariate regression showed no significant association between simulation duration and birthweight (adjusted β : 4.19, 95% confidence interval [CI]: −13.86 to 22.23; p = 0.6494) or gestational age (GA) (adjusted β : −0.01, 95% [CI]: −0.09 to 0.06; p = 0.7403) Categorical analysis of neonatal outcomes, including low birthweight (LBW) (adjusted Odds Ratio [OR]: 0.94, 95% [CI]: 0.70 to 1.25; p = 0.6501), macrosomia (adjusted OR: 0.95, 95% [CI]: 0.78 to 1.16; p = 0.6294), small for gestational age (SGA) (adjusted OR: 0.95, 95% [CI]: 0.75 to 1.19; p = 0.6465), large for gestational age (LGA) (adjusted OR: 1.02, 95% [CI]: 0.85 to 1.21; p = 0.8542) and preterm (adjusted OR: 0.93, 95% [CI]: 0.77 to 1.11; p = 0.4191), revealed no associations with stimulation duration. PSM analysis confirmed these findings. Conclusions Prolonged ovarian stimulation does not appear to increase adverse neonatal outcomes in singleton newborns after autologous fET.
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