编码(内存)
计算机科学
耗散系统
动态规划
程序设计范式
程序设计语言
算法
人工智能
物理
量子力学
作者
Luojia Wang,Zhongzhong Wang,Wang Luo,Heping Zhao,Guoming Xie
出处
期刊:ACS applied bio materials
[American Chemical Society]
日期:2024-12-04
标识
DOI:10.1021/acsabm.4c01366
摘要
Living systems have some of the most sophisticated reaction circuits in the world, realizing many incredibly complex functions through a variety of simple molecular reactions, in which the most notable feature that distinguishes them from artificial molecular reaction networks is the precise control of reaction times and programmable expression. Here, we exploit the hydrolysis-directed nature of λ exonuclease and the programmed responses of the dynamic nanotechnology of nucleic acids to construct a simple, complete, and powerful set of temporally programmed circuits. This system can arbitrarily regulate the degradation rate of the blocker, thereby delaying the nucleic acid chain substitution reaction with less signal leakage. In addition, the powerful dynamic reaction network of nucleic acids enabled us to control the programmed execution of a wide range of reactions in different fields. We have developed a simple strategy to introduce precise control of the time dimension into nucleic acid reaction circuits, which greatly enriches the functionality and applicability of the reaction programs, which can be easily used as timers, compilers, converters, etc. The simplicity, precision, stability, and versatility of such dynamic temporal programming circuits greatly expand the potential of artificial molecular reaction networks for more complex practical applications in biochemistry and molecular biology.
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