Mechanotransduction in the Perivascular Adipose Tissue

Perivascular adipose tissue is of compelling interest when considering tissue mechanotransduction. Because of its location around a vessel, perivascular adipose tissue experiences from high (artery) to low (vein) pressures, pressures that are cyclical in nature. With blood pressure change, such as the elevation of pressure in hypertension, the question has been raised as to whether perivascular adipose tissue senses such changes, evidenced by a response that can be genetic, structural, or mechanical in nature. Here, we briefly review the following knowledge and data that support the ability of perivascular adipose tissue to both (mechano)sense and (mechano)respond.