Synthesis of Polyamides Bearing Directing Groups and Their Catalytic Depolymerization

We report a directing group (DG)-enabled strategy for polyamide depolymerization. Pyridine-based DGs selectively interact with In(III) catalysts, activating amide bonds for catalytic cleavage via alcoholysis. The process achieves efficient depolymerization of DG-introduced polyamides into recyclable monomers, providing a sustainable chemical recycling approach for robust polyamides.