碱性成纤维细胞生长因子
再生(生物学)
明胶
脊髓
脊髓损伤
自愈水凝胶
生物医学工程
中枢神经系统
材料科学
化学
生长因子
细胞生物学
医学
神经科学
生物
高分子化学
内科学
生物化学
受体
作者
Xiaohong Chen,Lei Ren,Hui Zhang,Yangnan Hu,Menghui Liao,Yingbo Shen,Kai-Chen Wang,Jiaying Cai,Hong Cheng,Jiamin Guo,Yanru Qi,Hao Wei,Xiaokun Li,Luoran Shang,Jian Xiao,Jingwu Sun,Renjie Chai
标识
DOI:10.1002/smmd.20220038
摘要
Abstract Spinal cord injury is a severe central nervous system injury, and developing appropriate drug delivery platforms for spinal nerve regeneration is highly anticipated. Here, we propose a basic fibroblast growth factor (bFGF)‐loaded methacrylate gelatin (GelMA) hydrogel microsphere with ideal performances for spinal cord injury repair. Benefitting from the precise droplet manipulation capability of the microfluidic technology, the GelMA microspheres possess uniform and satisfactory size and good stability. More importantly, by taking advantage of the porous structures and facile chemical modification of the GelMA microspheres, bFGF could be easily loaded and gradually released. By co‐culturing with neural stem cells, it is validated that the bFGF‐loaded GelMA microspheres could effectively promote the proliferation and differentiation of neural stem cells. We also confirm the effective role of the bFGF‐loaded GelMA microspheres in nerve repair of spinal cord injury in rats. Our results demonstrate the potential value of the microspheres for applications in repairing central nervous system injuries.
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