フロキサン環への置換基導入反応の開発と光に応答して一酸化窒素を放出するフロキサン分子の創製

Furoxan (1,2,5-oxadiazole-2-oxide), categorized into a heteroaromatic compound, is a potentially useful drug-like molecule. However, due to the vulnerability of furoxan rings to ring-opening under various reaction conditions, there have been sporadic reports on its efficient synthesis; therefore, applied research on furoxan is relatively unexplored. We report herein our recent contribution to this research area. The unique photo-induced nitric oxide donors based on furoxan architecture are also represented.