An international multidisciplinary consensus statement on MAFLD and the risk of CVD

医学 肝病学 语句(逻辑) 结直肠外科 多学科方法 梅德林 公共卫生 重症监护医学 家庭医学 内科学 腹部外科 病理 政治学 法学
作者
Xiaodong Zhou,Giovanni Targher,Christopher D. Byrne,Virend K. Somers,Seung Up Kim,C. Anwar A. Chahal,Vincent Wai–Sun Wong,Jingjing Cai,Michael D. Shapiro,Mohammed Eslam,Philippe Gabríel Steg,Ki‐Chul Sung,Anoop Misra,Jian-Jun Li,Carlos Brotons,Yuli Huang,George Papatheodoridis,Aijun Sun,Yusuf Yılmaz,Wah‐Kheong Chan
出处
期刊:Hepatology International [Springer Science+Business Media]
卷期号:17 (4): 773-791 被引量:98
标识
DOI:10.1007/s12072-023-10543-8
摘要

Fatty liver disease in the absence of excessive alcohol consumption is an increasingly common condition with a global prevalence of ~ 25-30% and is also associated with cardiovascular disease (CVD). Since systemic metabolic dysfunction underlies its pathogenesis, the term metabolic (dysfunction)-associated fatty liver disease (MAFLD) has been proposed for this condition. MAFLD is closely intertwined with obesity, type 2 diabetes mellitus and atherogenic dyslipidemia, which are established cardiovascular risk factors. Unlike CVD, which has received attention in the literature on fatty liver disease, the CVD risk associated with MAFLD is often underestimated, especially among Cardiologists.A multidisciplinary panel of fifty-two international experts comprising Hepatologists, Endocrinologists, Diabetologists, Cardiologists and Family Physicians from six continents (Asia, Europe, North America, South America, Africa and Oceania) participated in a formal Delphi survey and developed consensus statements on the association between MAFLD and the risk of CVD. Statements were developed on different aspects of CVD risk, ranging from epidemiology to mechanisms, screening, and management.The expert panel identified important clinical associations between MAFLD and the risk of CVD that could serve to increase awareness of the adverse metabolic and cardiovascular outcomes of MAFLD. Finally, the expert panel also suggests potential areas for future research.
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