胰岛素抵抗
认知
痴呆
认知功能衰退
医学
胰岛素
疾病
阿尔茨海默病
糖尿病
病因学
神经影像学
心理学
生物信息学
精神科
内科学
内分泌学
生物
作者
Anne B. Kim,Zoe Arvanitakis
出处
期刊:Obesity
[Wiley]
日期:2023-05-19
卷期号:31 (6): 1486-1498
被引量:8
摘要
Abstract Chronic diseases of aging are increasingly common. Dementia, often due to multiple etiologies including Alzheimer disease (AD), is at the forefront. Previous studies have reported higher rates of dementia among persons with diabetes, yet less is known about how insulin resistance relates to cognition. This article reviews recently published data on the relationship of insulin resistance to cognition and AD, and remaining knowledge gaps in the field are discussed. A structured review of studies was conducted over a 5‐year period, investigating insulin and cognitive function in adults with a baseline mean age of ≥65 years. This search yielded 146 articles, of which 26 met the predetermined inclusion and exclusion criteria. Among the nine studies that specifically examined insulin resistance and cognitive dysfunction and/or decline, eight studies suggest an association, but some only in subanalyses. Results are mixed in studies relating insulin to structural and functional changes on brain imaging, and data on intranasal insulin for cognition remain unclear. Future avenues are proposed to elucidate the impact of insulin resistance on brain structure and function, including cognition, in persons with and without AD.
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