MANDELIC ACID: ORGANOCATALYST FOR EFFICIENT SYNTHESIS OF SECONDARY AMINES FROM ALDEHYDES AND PRIMARY AMINES

Mandelic acid was found to be gentle and efficient organocatalyst for the synthesis of diversified secondary amines from aldehydes primary amines via imine using Hantzsch DHP ester which act as a hydrogen source in one-pot manner under mild conditions. The green and inexpensive process described herein requires only catalytic amount of mandelic acid and provides quick access to the structurally diverse amines in high yields under mild conditions.