Manganese‐Based Nanozymes: Preparation, Catalytic Mechanisms, and Biomedical Applications

Abstract Manganese (Mn) has attracted widespread attention due to its low‐cost, nontoxicity, and valence‐rich transition. Various Mn‐based nanomaterials have sprung up and are employed in diverse fields, particularly Mn‐based nanozymes, which combine the physicochemical properties of Mn‐based nanomaterials with the catalytic activity of natural enzymes, and are attracting a surge of research, especially in the field of biomedical research. In this review, the typical preparation strategies, catalytic mechanisms, advances and perspectives of Mn‐based nanozymes for biomedical applications are systematically summarized. The application of Mn‐based nanozymes in tumor therapy and sensing detection, together with an overview of their mechanism of action is highlighted. Finally, the prospective directions of Mn‐based nanozymes from five perspectives: innovation, activity enhancement, selectivity, biocompatibility, and application broadening are discussed.