金黄色葡萄球菌
人性化鼠标
骨髓炎
肺炎
毒力
免疫系统
败血症
病菌
人类病原体
免疫学
排序酶A
葡萄球菌感染
医学
微生物学
生物
细菌
内科学
生物化学
遗传学
基因
作者
Ping Zheng,Fang Liu,Jinzhao Long,Yuefei Jin,Shuaiyin Chen,Guangcai Duan,Haiyan Yang
标识
DOI:10.1093/infdis/jiad253
摘要
Abstract Staphylococcus aureus (S. aureus) is an important pathogen for humans and can cause a wide range of diseases, from mild skin infections, severe osteomyelitis to fatal pneumonia, sepsis, and septicemia. The mouse models have greatly facilitated the development of S. aureus studies. However, due to the substantial differences in immune system between mice and humans, the conventional mouse studies are not predictive of success in humans, in which case humanized mice may overcome this limitation to some extent. Humanized mice can be used to study the human-specific virulence factors produced by S. aureus and the mechanisms by which S. aureus interacts with humans. This review outlined the latest advances in humanized mouse models used in S. aureus studies.
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