化学
试剂
芳基
电泳剂
氘
烷基
卤化物
组合化学
生物分子
反应性(心理学)
有机化学
药物化学
催化作用
生物化学
量子力学
医学
物理
病理
替代医学
作者
Yanyang Zhang,Yishuo Ren,Jian Zhang,Shaoli Liu,Yahui Li
标识
DOI:10.1002/cjoc.202300349
摘要
Comprehensive Summary A deuterated methylthiolating reagent with a broad spectrum, designated as DMTP, has been ingeniously formulated. This new reagent can be produced with high efficiency through the simple combination of commercially available methyl 3‐thiopropanoate and CD 3 I. This novel SCD 3 reagent exhibits excellent reactivity with electrophiles such as alkyl iodides, benzyl chlorides, aryl halides (I, Br) and aryl triflates, resulting in high levels of deuterium content (99% D). Representative deuterated methylthiolated biomolecules, such as Sulfoxaflor, have been synthesized for use in pharmaceutical discovery and development.
科研通智能强力驱动
Strongly Powered by AbleSci AI