Geometric Mismatch Promotes Anatomic Repair in Periorbital Bony Defects in Skeletally Mature Yucatan Minipigs

脚手架 解剖 骨生长 再生(生物学) 3d打印 生物医学工程 材料科学 医学 生物 细胞生物学 内科学
作者
Srujan Singh,Yuxiao Zhou,Ashley L. Farris,Emma C. Whitehead,Ethan L. Nyberg,Aine N. O'Sullivan,Nicholas Zhang,Alexandra N. Rindone,Chukwuebuka C. Achebe,Wojciech Zbijewski,W. M. Grundy,David S. Garlick,Nicolette D. Jackson,Dara L. Kraitchman,Jessica Izzi,Joseph Lopez,Michael P. Grant,Warren L. Grayson
出处
期刊:Advanced Healthcare Materials [Wiley]
卷期号:12 (29)
标识
DOI:10.1002/adhm.202301944
摘要

Abstract Porous tissue‐engineered 3D‐printed scaffolds are a compelling alternative to autografts for the treatment of large periorbital bone defects. Matching the defect‐specific geometry has long been considered an optimal strategy to restore pre‐injury anatomy. However, studies in large animal models have revealed that biomaterial‐induced bone formation largely occurs around the scaffold periphery. Such ectopic bone formation in the periorbital region can affect vision and cause disfigurement. To enhance anatomic reconstruction, geometric mismatches are introduced in the scaffolds used to treat full thickness zygomatic defects created bilaterally in adult Yucatan minipigs. 3D‐printed, anatomically‐mirrored scaffolds are used in combination with autologous stromal vascular fraction of cells (SVF) for treatment. An advanced image‐registration workflow is developed to quantify the post‐surgical geometric mismatch and correlate it with the spatial pattern of the regenerating bone. Osteoconductive bone growth on the dorsal and ventral aspect of the defect enhances scaffold integration with the native bone while medio‐lateral bone growth leads to failure of the scaffolds to integrate. A strong positive correlation is found between geometric mismatch and orthotopic bone deposition at the defect site. The data suggest that strategic mismatch >20% could improve bone scaffold design to promote enhanced regeneration, osseointegration, and long‐term scaffold survivability.
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