Rh(I)-catalyzed enantioselective (3 + 2) transannulations of 1,2,3-thiadiazoles with P -chiral monodentate phosphines

AbstractAs a proof of concept, P-chiral monodentate phosphines, which were inactive in promoting the transannulations of 1,2,3-thiadiazoles, were proven viable in the asymmetric catalytic (3 + 2) transannulations of 1,2,3-thiadiazoles with a strained bicyclic alkene. Polycyclic dihydrothiophenes with four newly formed stereocenters are generated in moderate 19-72% yields and 11-27% enantiopurities.Keywords: Asymmetric catalysisP-chiralitymonodentate phosphinestransannulation1,2,3-thiadiazole Disclosure statementNo potential conflict of interest was reported by the authors.Additional informationFundingThis work is financially supported by the National Natural Science Foundation of China (no. 21602010), and the Fundamental Research Funds for the Central Universities (nos. XK1802-6 and 12060093063).