A potential novel therapy addressing RNA oxidative damage in AKI

Oxidative stress plays a vital role in the pathogenesis of various diseases, as excessive free radicals can damage cellular components including nucleic acid, lipid, and protein, resulting in progressive physiological dysfunction. Compared with DNA, lipid, and protein, RNA is indicated to be more vulnerable to oxidative damage. 1 Kong Q. Lin C.L.G. Oxidative damage to RNA: mechanisms, consequences, and diseases. Cell. Mol. Life Sci. 2010; 67: 1817-1829 Crossref PubMed Scopus (256) Google Scholar However, RNA oxidation has drawn little attention, and even today, the damage mechanism remains obscure, thus making this an area with great potential for exploration. Targeting RNA oxidation by ISG20-mediated degradation is a potential therapeutic strategy for acute kidney injuryJia et al.Molecular TherapyJuly 13, 2023In BriefYi and colleagues provide direct evidence that RNA oxidation actually contributes to the pathogenesis of AKI and ISG20 protects against AKI through mediating the degradation of oxidized RNA, thereby preventing the activation of ER stress and UPR cascades. Targeting ISG20-handled RNA oxidation may be an innovative therapeutic strategy for AKI. Full-Text PDF Open Access