间充质干细胞
衰老
返老还童
骨关节炎
再生医学
滑膜关节
医学
细胞生物学
干细胞
软骨
表型
再生(生物学)
生物
生物信息学
关节软骨
病理
老年学
解剖
遗传学
基因
替代医学
作者
Tatiana Sekelova,Ľuboš Danišovič,Michaela Čeháková
标识
DOI:10.1177/09636897231200065
摘要
Mesenchymal/medicinal stem/signaling cells (MSCs), well known for regenerative potential, have been involved in hundreds of clinical trials. Even if equipped with reparative properties, aging significantly decreases their biological activity, representing a major challenge for MSC-based therapies. Age-related joint diseases, such as osteoarthritis, are associated with the accumulation of senescent cells, including synovial MSCs. An impaired ability of MSCs to self-renew and differentiate is one of the main contributors to the human aging process. Moreover, senescent MSCs (sMSCs) are characterized by the senescence-messaging secretome (SMS), which is typically manifested by the release of molecules with an adverse effect. Many factors, from genetic and metabolic pathways to environmental stressors, participate in the regulation of the senescent phenotype of MSCs. To better understand cellular senescence in MSCs, this review discusses the characteristics of sMSCs, their role in cartilage and synovial joint aging, and current rejuvenation approaches to delay/reverse age-related pathological changes, providing evidence from in vivo experiments as well.
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