氮丙啶
全合成
戒指(化学)
立体化学
化学
组合化学
计算机科学
有机化学
作者
Fabian Schneider,Yinliang Guo,You-Chen Lin,Kelly Eberle,Debora Chiodi,Jonathan Greene,Chenxin Lu,Phil S. Baran
标识
DOI:10.26434/chemrxiv-2023-kw0xn
摘要
The first total synthesis of the potent antimicrobial agent dynobactin A is disclosed. This synthesis capitalizes on the hidden symmetry present in this complex decapeptide by enlisting an aziridine ring opening strategy to access b-branched amino acids. Featuring a number of unique maneuvers to navigate inherently sensitive and epimerizable functional groups, this convergent approach proceeds in only 14 steps (LLS) from commercial materials and should facilitate the synthesis of numerous analogs for medicinal chemistry studies.
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