免疫原性
表位
衣壳
加德西
人乳头瘤病毒疫苗
病毒学
宫颈癌
对接(动物)
计算生物学
生物
免疫系统
医学
免疫学
HPV感染
遗传学
癌症
抗体
病毒
护理部
作者
Egy Rahman Firdaus,Apon Zainal Mustopa,Lita Triratna,Gita Syahputra,Maritsa Nurfatwa
标识
DOI:10.31557/apjcp.2022.23.7.2243
摘要
Background: Human Papillomavirus type 52 (HPV 52) is considered one of the threatening HPV types inducing cervical cancer worldwide. This study was conducted to address strategies of an effective vaccine against cervical cancer using computational approaches immuno-informatics and molecular docking. Methods: Major capsid protein L1 and L2 HPV 52 (L1 and L2 HPV 52) sequences were investigated by multiple analyses including B and T cell epitope, toxicity, allergenicity, Immunogenicity, epitope conservancy, population coverage, and molecular docking. Results: L1 and L2 HPV 52 showed a conserved sequence among amino acid levels. Q307K, S383D/N, and D473E are found as major mutations in L1, while mutations in L2 are S122T, Q247H, L247S, and E365D. Multiple epitopes were identified and elicited strong immune responses against cross types of HPV in various HLA populations. To enhance vaccine effectiveness that allows having cross-protection over HPV types, N terminus HPV L2 was analyzed suggesting multi-candidates chimeric L1/L2 vaccine design. Conclusion: This study shed a light on a useful pipeline with robust analysis for effective vaccine production.
科研通智能强力驱动
Strongly Powered by AbleSci AI